https://www.nordmanlab.com/home daily 1.0 2026-07-06 https://images.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/08f836d7-c266-4ee3-ae4b-723b2b821ac6/Drosophila+and+Replication+%28Nordman+Lab%27s+version%29.png Home - Regulation of genome duplication requires exquisite control to ensure proper transmission of genetic material from mother cell to daughter cell and to prevent the genome aberrations that are associated with cancer cells. Importantly, the replication machinery must respond to changes in chromatin structure and cell cycle parameters that are associated with cellular differentiation to maintain genome integrity. Although this is a fundamental aspect of genome duplication, the underlying molecular mechanisms and critical factors responsible for responding to these changes remain poorly understood. Drosophila provides an ideal model system to understand, mechanistically, how the DNA replication program responds to changes in cellular differentiation and development. 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https://images.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/cf43d1d4-43b2-46e2-8d73-99f9ca5ebcc8/Graphical_Abstract+copy.jpg Our Research - Rif1 control of replication during development Our goal is to dissect mechanistically how Rif1 controls DNA replication using the powerful developmental systems of Drosophila. Work from multiple labs has revealed that Rif1 controls many aspects of DNA replication including; helicase activation, helicase loading and replication fork progression. The underlying molecular mechanisms that Rif1 uses to target and regulate key replication proteins remains unclear. We are using a combination of biochemical, proteomic, genetic, genomic and quantitative live imaging approaches in the context of development to understand Rif1 function. https://images.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/a76ed92c-97b7-4215-889f-f655b5dcd30d/ORC.jpeg Our Research - Regulation of ORC activity and localization The Origin Recognition Complex (ORC) binds to thousands of sites throughout the genome to initiate DNA replication. The level of ORC binding throughout the genome is essential for efficient DNA replication and to maintain genome stability. In metazoans, ORC binding is sequence independent and highly influenced by chromatin. While we can map ORC-binding sites throughout metazoan genomes, understanding how ORC is loaded onto chromatin is still an outstanding question in the field. Equally important, is understanding how posttranslational modifications of ORC affect its ability to load the helicase throughout the genome. We are employing a diverse set of approaches to answer these questions. https://video.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/f9cf392f-e658-4da7-9d38-130b4f474586/playlist.m3u8 https://video.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/f9cf392f-e658-4da7-9d38-130b4f474586/thumbnail Our Research Our Research https://video.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/5a652f6a-cb9c-4c92-a451-76da5de65b8c/playlist.m3u8 https://video.squarespace-cdn.com/content/v1/626c4fe56a62bf1215bebb12/5a652f6a-cb9c-4c92-a451-76da5de65b8c/thumbnail Our Research Our Research